Highlevel prescribing trends for antileprotic drugs bnf section 5. Ramakrishnan and colleagues have developed a platform for highthroughput, in vivo antitubercular drug screening that features the use of larval zebrafish infected with a model mycobacterium species. Deepak k gupta slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Cutaneous mycoses are mostly caused by keratinophilic filamentous fungi called dermatophytes. Future articles will feature other compounds used for the treatment of cancer, such as antimetabolites. In india, one is eligible to opt for this education course after successfully completing standard twelve in science stream with physics, chemistry and either biology as subjects. Many consider them the drugs of choice for seizures only in infants. If your institution subscribes to this resource, and you dont have a myaccess profile, please contact your librarys reference desk for information on how to gain access to this resource from offcampus. The evolution of antifungal drug therapy continued advancement of medical science offers lifesaving treatment options for a variety of hematologic, oncologic, and rheumatologic conditions. Antiinfectives and antibiotics antibiotics penicillin. They act upon rapidly dividing cancer cells and destroy them. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The mycobacteria that cause tuberculosis and leprosy are very slow growing, so therapy must be continued for relatively long periods of time.
Salmaan keshavjee and colleagues oct 18, p 14031 achieved a 48% cure or treatment completion rate for extensively drugresistant tuberculosis xdrtb, despite the fact that 96%, 46%, and around 60% of the patients with xdrtb were resistant to the secondline antitubercular drugs ofloxacin, capreomycin, and ethionamide, respectively. Ppt antiepileptic drugs powerpoint presentation free. Richard w dudley department of pharmaceutical sciences, the university of findlay, usa corresponding author. Anticancer agents in medicinal chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anticancer agents. Many act against specific parasites, and few are devoid of significant toxicity to host cells. Pharmacology is the study of interaction of drugs with living organisms. Regulatory frecommendations or nonclinical studies of. Overview of research and development for anticancer drugs. To prevent the emergence of resistant strains, it is vital to employ combination therapy with as many as four or five agents to which the organism is sensitive. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects.
A leprostatic agent is a drug that interferes with proliferation of the bacterium that causes. The medicinal chemistry of anticancer drugs is a broad topic. Treatment of extensively drugresistant tuberculosis the lancet. Pharmacokinetic dapsone, combined with other antileprotic agents like rifampicin and clofazimine, is used in the treatment of both multibacillary and paucibacillary m. Drugs used in tuberculosis and leprosy basic concepts in. Overview of research and development for anticancer drugs junjie xu1, wenwei mao2,3 1shanghai jiao tong university school of medicine, shanghai, china 2lab of microbial and biochemical pharmaceutical, school of pharmacy, shanghai jiao tong university, shanghai, china. Among the antileprotic drugs, only clofazimine inhibited the enzymic activities whereas dapsone had no effect whatsoever. Antimicrobial drug discovery has been stymied by the lack of relevant models to predict those compounds that will be active in vivo.
Directly kill trophozoite responsible for production of cyst single. Convert pdf files to and from any microsoft office formaton the desktop with nitro pro or in any web browser with nitro cloud. A leprostatic agent is a drug that interferes with proliferation of the bacterium that causes leprosy the following agents are leprostatic agents. The most common site of involvement is the ileocaecal region, other locations of involvement, in order of descending frequency, are the ascending colon, jejunum, appendix, duodenum, stomach. Diloxanide furoate luminal amoebicide highly effective against cysts pharmacokinetics. In this article, dnainteractive antineoplastic agents are discussed. Information and translations of antileprotic in the most comprehensive dictionary definitions resource on the web. The polyenes nystatin, amphotericin b, natamycin bind with sterols in the fungal cell. Smallpdf will upload and start to work on the file right away. The most common types are mycoses such as athletes foot, ringworm, candidiasis thrush, serious systemic infections such as cryptococci meningitis.
New formulations of antiepileptic drugs for the management of epilepsy extendedrelease formulations. Leprosy or hansens disease leprosy is caused mainly by mycobacterium leprae, a rod shaped bacillus that is an. Susceptibility test interpretive criteria labeling for ndas and andas guidance for industry. Who treatment guidelines for drug resistant tuberculosis. Wait for the extraction to finish and download your ppt. Antifungal drugs can be divided into polyenes, imidazole, and triazole derivatives, allylamines, and others. They can be used alone singledrug therapy or several at once combination therapy. Phenazine derivative clofaziminephenazine derivative clofazimine lamprene 3. Antifungal agents spectrum of activity, pharmacology, and clinical indications jeniel e. Modes of action and mechanisms of resistance in mycobacterium leprae.
Firstline agents for treatment of active tb consist of isoniazid, a rifamycin rifampin or less frequently either rifapentine or rifabutin, pyrazinamide, and ethambutol. A free powerpoint ppt presentation displayed as a flash slide show on id. Leprosy or hansens disease leprosy is caused mainly by mycobacterium leprae, a rod shaped bacillus that is an obligate intracellular only grows inside of certain human and animal cells bacterium. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Pharma a also called diploma in pharmacy, is pursued by the students in the medical field of pharmacy.
Nov 15, 2017 leprosy, also called hansens disease, is a neglected tropical disease that has affected humanity for centuries. Although considered one of the safest drugs, it has sedative effects. The sulfones metabolism by acetylation in the liver, and 70 to 80% of drug is excreted in the urine as metabolites. Scribd is the worlds largest social reading and publishing site. A power point presentation on the drugs used in leprosy antileprotic drugs suitable for undergraduate level medical students and also others slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Antiepileptic drugs for the management of epilepsy goals of treatment for epilepsy control of seizures minimal adverse events good. Ppt anthelmintic drugs powerpoint presentation free to. Abdul latif mahesar department of medical pharmacology ksu ivermectin con d strongyloidiasis. Dismukes from the department of medicine, division of infectious diseases, university of alabama at birmingham school of medicine in the united states, only 10 antifungal drugs are currently approved by the food and drug administration fda for the therapy of systemic fungal infections. It also includes history, source, physicochemical properties, dosage forms, methods of administration, absorption, distribution mechanism of action, biotransformation, excretion, clinical uses and adverse effects of drugs. Safe, minimal side effects and increased patient compliance. Experts involved in the development of the who treatment guidelines for. Edit any pdf file, including all images, paragraphs, and pages. Antiinfectives and antibiotics free download as powerpoint presentation.
Richard w dudley, department of pharmaceutical sciences, the university of findlay, findlay, oh 45840, usa. Antihelminthic drugs have diverse chemical structures, mechanisms of action, and properties. Anticancer drugs are also called antineoplastic agents or chemotherapeutic agents. Introduction leprosy is a disease caused by mycobacterium leprae lesions of skin and peripheral nerves are characteristic feature of this disease 3. An in vivo platform for rapid highthroughput antitubercular. If you continue browsing the site, you agree to the use of cookies on this website.
Pharmacologic agents for treatment of tuberculosis tb are utilized in a hierarchical fashion. Ppt antiepileptic drugs powerpoint presentation free to. Introduction leprosy is a disease caused by mycobacterium leprae lesions of skin and peripheral nerves are characteristic feature of this disease. Antifungal agents list of high impact articles ppts. A power point presentation on the drugs used in leprosy antileprotic drugs suitable for undergraduate level medical students and also. It is a devastating disease that can lead to disfigurement and disability. Leprosy is a chronic disease caused by the bacteria mycobacterium leprae that causes damage to the skin and the peripheral nervous system. Type i type ii erythema nodosum leprosumrelapse in lepromatous type iii hsr slow and insiduous new crops of nodules glomerulonephritis, hepatitis,conjunctivitis keratitis,fever no tenderness reversalupgrading or downgrading in tuberculoid type iv hsr abrupt and sudden existing lesionedema,erythema tenderness. You can explore prescribing trends for this section by ccg, or learn more about this site.
Clarithromycin only macrolide with antileprotic act. Chaulmoogra oil was used an antileprotic agent in indian medicine for centuries 1949 cochrane et al employed parental dapsone at chenglepet, madras. Antileprotic activity of chemically defined molecules we founded 17 chemically defined natural molecules reported in the literature which have been identified as antileprotic activity table 2. Six groups 1 antibiotics amphotricin b,amb, nystatin, greiofulvin. Antifungal agents are the substances which destroy or prevent the growth of fungi.
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